反应详情

To a −78° C. solution of 4(R)-phenyl-2-oxazolidinone (340 g, 2.08 mol) in THF (8000 mL), is added n-BuLi (2.5 M, 920 mL, 1.1 eq). The reaction mixture is stirred for 20 minutes and 2-fluorobenzeneacetyl chloride (358 g, 2.08 mol) is added. After 2 hours the reaction mixture is quenched with saturated NH4Cl solution (1×1000 mL). The organic layer is separated, washed with H2O (1×1000 mL), saturated NaCl solution (2×1000 mL) and then concentrated in vacuo. This procedure yields 3-[(2-fluorophenyl)-acetyl]-4(R)-phenyl-2-oxazolidinone.

1. customAfter 2 hours the reaction mixture is quenched with saturated NH4Cl solution (1×1000 mL)
2. customThe organic layer is separated
3. washwashed with H2O (1×1000 mL), saturated NaCl solution (2×1000 mL)
4. concentrationconcentrated in vacuo