反应详情

温度

22.5 °C

A solution of 50.0 g of o-fluorophenylacetic acid in 150 mL of toluene and 2.2 g of N,N-dimethylformamide is added to 50.2 g (31.7 mL) of thionyl chloride with efficient stirring over a period of 20 minutes while maintaining an internal temperature of 20-25° C. After addition, the mixture is stirred for 3 hours at 20-25° C., and concentrated to dryness under reduced pressure (66-76 mm Hg, bath temperature 65-70° C.) to obtain 2-fluorobenzenacetyl chloride as an oil.

1. additionAfter addition
2. stirringthe mixture is stirred for 3 hours at 20-25° C.
3. concentrationconcentrated to dryness under reduced pressure (66-76 mm Hg, bath temperature 65-70° C.)