Ammonia → HCID 21266081, compound

HRID 566312Notes

Reaction equation

HRID 566312 reaction equation
[NH2:1][C:2]1[N:6]([CH:7]([CH3:17])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:5]=[CH:4][C:3]=1[C:18]#[N:19].N.[OH:21]O>C(O)C>[NH2:1][C:2]1[N:6]([CH:7]([CH3:17])[CH2:8][CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:5]=[CH:4][C:3]=1[C:18]([NH2:19])=[O:21]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 784Hydrogen PeroxideHCID 15407141HCID 15407141, compound

Product 1

HCID 21266081HCID 21266081, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

512 mg (2.02 mmol) of 5-amino-1-(1-methyl-4-phenyl-butyl)-1H-pyrazole-4-carbonitrile are stirred for 3 hours at room temperature with 25 ml of concentrated aqueous NH3, 20 ml of ethanol and 5 ml of 30% strength H2O2. The non-aqueous solvent is removed in vacuo, and the solid which has precipitated is filtered off with suction and dried.

Workup

  1. customThe non-aqueous solvent is removed in vacuo
  2. customthe solid which has precipitated
  3. filtrationis filtered off with suction
  4. customdried

Sources & evidence

ORD record
ord-60548812123647f18496f8942635983f
Source dataset
uspto-grants-2001_01
Patent number
US06174884B1

Reaction notes

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