反应详情

Starting from 400 g (1.32 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 578 mg (3.44 mmol) of 4-methylphenylacetylchloride, the title compound is prepared analogously to the protocol of Example 13. This gives 117 mg (21%) of the diastereomer which elutes more rapidly, M.p.: 133° C., and 75 mg (13.6%) of the diastereomer which elutes more slowly, M.p.: 136° C.