反应详情

20 mg (0.066 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 41 mg (0.210 mmol) of methyl 3,4-methylenedioxyphenylacetate are refluxed for 6 hours in 1.06 ml of a 0.5M ethanolic potassium tert-butoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 19 mg (64%) of a solid, Rf=0.20 (dichloromethane/methanol=15:1).

1. customthe phases are separated
2. customPurification by chromatography