反应详情

6 mg (0.02 mmol) of 5-amino-3-ethyl-1-(4-decyl)-1H-pyrazole-4-carboxamide and 20 mg (0.064 mmol) of methyl 4-N-methylpiperazinosulphonylphenylacetate are refluxed for 6 hours in 0.3 ml of a 0.5M ethanolic potassium tert-butoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate have been added, the phases are separated. Purification by chromatography gives 4.3 mg (38%) of a solid, Rf=0.50 (dichloromethane/methanol=15:1).

1. customthe phases are separated
2. customPurification by chromatography