1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine → N6,N6-Dimethyl-N4-(1-pyridin-2-ylmethyl-1H-indazol-5-yl)-pyrido[3,4-d]pyrimidine-4,6diamine Hydrochloride

HRID 566396Notes

Reaction equation

HRID 566396 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH:10]=[N:9]1.[Cl:18][C:19]1[C:20]2[CH:28]=[C:27]([N:29]([CH3:31])[CH3:30])[N:26]=[CH:25][C:21]=2[N:22]=[CH:23][N:24]=1>>[ClH:18].[CH3:30][N:29]([CH3:31])[C:27]1[N:26]=[CH:25][C:21]2[N:22]=[CH:23][N:24]=[C:19]([NH:17][C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[N:9]=[CH:10]4)[C:20]=2[CH:28]=1

Participants

3

Reactant 2

HCID 219523661-(Pyridin-2-ylmethyl)-1H-indazol-5-amineHCID 227274534-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine

Product 1

HCID 22727464N6,N6-Dimethyl-N4-(1-pyridin-2-ylmethyl-1H-indazol-5-yl)-pyrido[3,4-d]pyrimidine-4,6diamine Hydrochloride

Procedure

Prepared according to Procedure A from 1-(2-Pyridylmethyl)indazol-5-ylamine and 4-chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine; δH[2H6]DMSO 11.75(1H,s), 9.92(1H,s), 8.62(1H,s), 8.55(1H,d), 8.24(1H,s), 8.14(1H,s), 7.75(4H,m), 7.33(1H,m), 7.08(1H,d), 5.82(2H,s), 3.20(6H,s); m/z (M+1+) 397.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0f9473da1bfa40c0b03277230ae92ebe
Source dataset
uspto-grants-2001_01
Patent number
US06174889B1

Reaction notes

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