HCID 9850019, compound → HCID 21266169, compound

HRID 566422Notes

Reaction equation

HRID 566422 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][CH:19]2[CH:24]([C:25]([NH:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])=[O:26])[CH2:23][CH:22]=[CH:21][CH2:20]2)=[O:16])[CH2:11][CH2:10]1>C(OCC)(=O)C>[ClH:1].[CH3:8][N:9]1[CH2:10][CH2:11][N:12]([C:15]([O:17][CH2:18][CH:19]2[CH:24]([C:25]([NH:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])=[O:26])[CH2:23][CH:22]=[CH:21][CH2:20]2)=[O:16])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 9850019HCID 9850019, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 21266169HCID 21266169, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (11.5 ml) was added to a solution of {6-[(octadecylamino)carbonyl]-3-cyclohexenyl}methyl 4-methyltetrahydro-1(2H)-pyrazinecarboxylate (16.43 g) in ethyl acetate (150 ml). After being stirred for 10 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate-ethanol mixed solution, thereby yielding the entitled compound (14.69 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with ethyl acetate-ethanol mixed solution

Sources & evidence

ORD record
ord-3369563b707a47eaa034725790a70a1a
Source dataset
uspto-grants-2001_01
Patent number
US06174885B1

Reaction notes

Loading…