反应详情

A mixture of 3-chloro-4,5,6,7-tetrahydro-1,2-benzisothiazol-4-one 24a (600 mg) and a solution of sodium (506 mg) in methanol (22 mL) was stirred at 90° C. for 1 h. The reaction mixture was evaporated and water (20 mL) was added to the residue. Extractions with methylene chloride (3×30 mL), drying and evaporation gave an oil. Column chromatography on silica gel (eluent: toluene-ethyl acetate 4:1) gave the title compound (251 mg). Mp 45-46° C.

1. customThe reaction mixture was evaporated
2. additionwater (20 mL) was added to the residue
3. extractionExtractions with methylene chloride (3×30 mL)
4. customdrying
5. customevaporation
6. customgave an oil