3-Aminophenol → HCID 18316812, compound

HRID 566480Notes

Reaction equation

HRID 566480 reaction equation
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C([O-])(O)=O.[Na+].[NH2:14][C:15]1[CH:16]=[C:17]([OH:21])[CH:18]=[CH:19][CH:20]=1>CO>[CH2:1]([NH:14][C:15]1[CH:16]=[C:17]([OH:21])[CH:18]=[CH:19][CH:20]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 3

HCID 115683-AminophenolHCID 123691-BromoheptaneHCID 516892Sodium Bicarbonate

Product 1

HCID 18316812HCID 18316812, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.11 mol of n-heptyl bromide and 0.1 mol of NaHCO3 are added to 0.1 mol of m-aminophenol in 150 ml of methanol and the mixture is refluxed for 5 h. After cooling, the mixture is filtered and the solvent is removed in vacuo. The oil which remains is fractionated in vacuo, to give 3-(n-heptylamino)phenol; b.p. 130-140° C. (8·10−5 torr), m.p. 27-30° C., yld. 62%.

Workup

  1. temperaturethe mixture is refluxed for 5 h
  2. temperatureAfter cooling
  3. filtrationthe mixture is filtered
  4. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-310a3b5499234e1299b5e0f430fdbedb
Source dataset
uspto-grants-2001_01
Patent number
US06174961B1

Reaction notes

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