HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → Di(tert-butyl) [4-(bromomethyl)benzoyl]phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Di(tert-butyl) (4-methylbenzoyl)phosphonate | HCID 54190661 | — |
| Catalyst | Benzoyl Peroxide | HCID 7187 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | Di(tert-butyl) [4-(bromomethyl)benzoyl]phosphonate | HCID 54361205 | 22.4% |
Reaction Steps
A mixture of di(tert-butyl) (4-methylbenzoyl)phosphonate (10 g), NBS (8.3 g), NaHCO3 (10 g) and benzoyl peroxide (0.1 g) in 200 mL of CCl4 was heated to reflux for 20 min. The mixture was cooled to room temperature, diluted with 200 mL of 10:1 hexane/EtOAc and filtered through a pad of silca gel. The filtrate was concentrated and the residue was swished from hexane to give 2.8 g of the title compound as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06174874B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-7329bc2c793c4ba3805ddb4ef22271bc |
| Source note | uspto-grants-2001_01 |