反应详情

A mixture of di(tert-butyl) (4-methylbenzoyl)phosphonate (10 g), NBS (8.3 g), NaHCO3 (10 g) and benzoyl peroxide (0.1 g) in 200 mL of CCl4 was heated to reflux for 20 min. The mixture was cooled to room temperature, diluted with 200 mL of 10:1 hexane/EtOAc and filtered through a pad of silca gel. The filtrate was concentrated and the residue was swished from hexane to give 2.8 g of the title compound as a beige solid.

1. temperaturewas heated
2. temperatureto reflux for 20 min
3. filtrationfiltered through a pad of silca gel
4. concentrationThe filtrate was concentrated