HRID566495

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OP(=O)(OC(C)(C)C)C(F)(F)c1ccc(CC(Cc2ccc(C(F)(F)P(=O)(OC(C)(C)C)OC(C)(C)C)cc2)(C(=O)OCc2ccccc2)C(=O)OCc2ccccc2)cc1

HCID21265761

未命名化合物

PRODUCTS

生成物

结构：O=C(OCc1ccccc1)C(Cc1ccc(C(F)(F)P(=O)(O)O)cc1)(Cc1ccc(C(F)(F)P(=O)(O)O)cc1)C(=O)OCc1ccccc1

HCID15485891

未命名化合物

收率 131%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22392675

未命名化合物

PROCEDURE

实验过程

A solution of dibenzyl 2,2-di{4-[(di-tert-butoxyphosphoryl) (difluoro)methyl]benzyl}malonate (100 mg) in 2 mL of 10:1 TFA/water was stirred for 0.5 h and then concentrated. The residue was dissolved in 5 mL of water and lyopholized to give 100 mg of the title compound as a beige solid.

WORKUP

后处理

concentrationconcentrated
dissolutionThe residue was dissolved in 5 mL of water

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-01e63c3d0a634c03967e7e761b22367b
来源数据集: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06174874B1
来源说明: uspto-grants-2001_01

反应 SMILES

C([O:5][P:6]([C:13]([F:65])([F:64])[C:14]1[CH:63]=[CH:62][C:17]([CH2:18][C:19]([CH2:40][C:41]2[CH:46]=[CH:45][C:44]([C:47]([P:50]([O:57]C(C)(C)C)([O:52]C(C)(C)C)=[O:51])([F:49])[F:48])=[CH:43][CH:42]=2)([C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])[C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])=[CH:16][CH:15]=1)([O:8]C(C)(C)C)=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O.O>[F:65][C:13]([F:64])([P:6]([OH:8])([OH:7])=[O:5])[C:14]1[CH:15]=[CH:16][C:17]([CH2:18][C:19]([CH2:40][C:41]2[CH:42]=[CH:43][C:44]([C:47]([F:48])([F:49])[P:50]([OH:57])([OH:52])=[O:51])=[CH:45][CH:46]=2)([C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])[C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])=[CH:62][CH:63]=1