Dibenzyl 2,2-di{4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonate → 2,2-Di{4-[difluoro(phosphono)methyl]benzyl}malonic acid, dibenzyl ester

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Reaction Steps

A solution of dibenzyl 2,2-di{4-[(di-tert-butoxyphosphoryl) (difluoro)methyl]benzyl}malonate (100 mg) in 2 mL of 10:1 TFA/water was stirred for 0.5 h and then concentrated. The residue was dissolved in 5 mL of water and lyopholized to give 100 mg of the title compound as a beige solid.

Provenance & Evidence