HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Fluoro-N-methoxy-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | N,O-Dimethylhydroxylamine | HCID 14232 | — |
| Reactant | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-Fluoro-N-methoxy-N-methylbenzamide | HCID 21265757 | — |
Reaction Steps
To a mixture of 3-fluorobenzoyl chloride (11.0 g, 6.70 mmol) and N,O-dimethylhydroxylamine.HCl in CHCl3 (70 mL) at 0° C. was added pyridine (14 mL) over 30 min. After a period of 3 h at room temperature, the reaction mixture was treated in the usual manner to give 12.5 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06174874B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-2499919546844c4493cec1cc97ddddbf |
| Source note | uspto-grants-2001_01 |