Hydrochloric Acid → 3-Fluoro-N-methoxy-N-methylbenzamide

HRID 566512Notes

Reaction equation

HRID 566512 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[CH3:11][NH:12][O:13][CH3:14].Cl.N1C=CC=CC=1>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([N:12]([O:13][CH3:14])[CH3:11])=[O:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 14232N,O-DimethylhydroxylamineHCID 743763-Fluorobenzoyl chloride

Product 1

HCID 212657573-Fluoro-N-methoxy-N-methylbenzamide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a mixture of 3-fluorobenzoyl chloride (11.0 g, 6.70 mmol) and N,O-dimethylhydroxylamine.HCl in CHCl3 (70 mL) at 0° C. was added pyridine (14 mL) over 30 min. After a period of 3 h at room temperature, the reaction mixture was treated in the usual manner to give 12.5 g of the title compound.

Workup

  1. additionthe reaction mixture was treated in the usual manner

Sources & evidence

ORD record
ord-2499919546844c4493cec1cc97ddddbf
Source dataset
uspto-grants-2001_01
Patent number
US06174874B1

Reaction notes

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