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HRID56652

反应详情

EQUATION

反应方程式

HRID 56652 的结构方程式

REACTANTS

反应物

2
结构：N#Cc1ccc(Cl)cc1B(O)O
HCID46738934

(5-Chloro-2-cyanophenyl)boronic acid

C7H5BClNO2

结构：CCC(C(=O)OC(C)(C)C)n1ccc(Br)cc1=O
HCID117622861

未命名化合物

PRODUCTS

生成物

1
结构：CCC(C(=O)OC(C)(C)C)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O
HCID117622863

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

PROCEDURE

实验过程

600 mg (purity 82%, 1.56 mmol) of tert-butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate (racemate) and 325 mg (1.8 mmol) of 5-chloro-2-cyanophenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) were reacted according to General Method 2A. Yield: 543 mg (purity 59%, 55% of theory)