HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-cyanophenylboronic acid → tert-Butyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-cyanophenylboronic acid | HCID 46738934 | — |
| Reactant | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate | HCID 117622861 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | tert-Butyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]butanoate | HCID 117622863 | — |
Reaction Steps
600 mg (purity 82%, 1.56 mmol) of tert-butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate (racemate) and 325 mg (1.8 mmol) of 5-chloro-2-cyanophenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) were reacted according to General Method 2A. Yield: 543 mg (purity 59%, 55% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-9a2de717170042578cf19f1175aeef13 |
| Source note | uspto-grants-2016_09 |