Ethyl Acetate → HCID 45262189, compound

HRID 566543Notes

Reaction equation

HRID 566543 reaction equation
[ClH:1].[CH3:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[CH:10][CH2:11][O:12][CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([C:21]([OH:23])=[O:22])[CH2:16]1.C(OCC)(=O)C>CO.[Pd]>[ClH:1].[CH3:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([C:21]([OH:23])=[O:22])[CH2:16]1

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 70231140HCID 70231140, compound

Product 1

HCID 45262189HCID 45262189, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The acid prepared in Example 26 (1.0 g, 2.4 mmol) was dissolved in methanol (20 ml) and stirred under an atmosphere of hydrogen for 1 h at room temperature in the presence of 10% palladium on carbon catalyst (50% aqueous paste) and then filtered. The filtrate was evaporated to dryness leaving a residue which was treated with ethyl acetate to give 0.8 g (80%) of the title compound as a solid.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness
  3. customleaving a residue which

Sources & evidence

ORD record
ord-955460f552a74cffa2e222a51242f797
Source dataset
uspto-grants-2001_01
Patent number
US06174898B1

Reaction notes

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