反应详情

A mixture of 1-(3-methoxyphenyl)-1-(2-methylphenyl)-1-propanol (26.2 g, 0.10 mol), isopropanol (300 ml) and a 6 N solution of sulphuric acid (150 ml) was stirred at room temperature for 2 h. The reaction mixture was neutralised with a 4 N sodium hydroxide solution and extracted with ethyl acetate (2×200 ml). The combined organic phases was dried (MgSO4) and the solvent was evaporated in vacuo. The residue was submitted to flash chromatography on silica gel (800 g) using n-heptane as eluent to give 18.4 g (76%) of 1-(3-methoxy-phenyl)-1-(2-methylphenyl)-1-propene.

1. extractionextracted with ethyl acetate (2×200 ml)
2. dry with materialThe combined organic phases was dried (MgSO4)
3. customthe solvent was evaporated in vacuo