Lithium Hydroxide → 2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoic acid

HRID 56659Notes

Reaction equation

HRID 56659 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]#[N:26])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:20][CH2:21][CH2:22][CH3:23])[C:15]([O:17]CC)=[O:16])[C:10](=[O:24])[CH:9]=2)[CH:7]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]#[N:26])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:20][CH2:21][CH2:22][CH3:23])[C:15]([OH:17])=[O:16])[C:10](=[O:24])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 117622689Ethyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoate

Product 1

HCID 1176228212-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoic acid

Procedure

113 mg (purity 95%, 0.29 mmol) of ethyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoate (racemate) were hydrolysed with lithium hydroxide according to General Method 6B. Yield: 64 mg (purity 78%, 50% of theory)

Sources & evidence

ORD record
ord-704eb649e64e412b8be51edf13d0ab27
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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