Sulfuryl chloride → HCID 15672346, compound

HRID 566597Notes

Reaction equation

HRID 566597 reaction equation
S(Cl)([Cl:4])(=O)=O.[Cl:6][C:7]1[C:12]([CH3:13])=[CH:11][C:10]([C:14]2[CH:18]=[C:17]([O:19][CH:20]([F:22])[F:21])[N:16]([CH3:23])[N:15]=2)=[C:9]([F:24])[CH:8]=1.C(=O)([O-])O.[Na+]>ClC(Cl)(Cl)Cl>[Cl:4][C:18]1[C:14]([C:10]2[CH:11]=[C:12]([CH3:13])[C:7]([Cl:6])=[CH:8][C:9]=2[F:24])=[N:15][N:16]([CH3:23])[C:17]=1[O:19][CH:20]([F:22])[F:21]

Participants

5

Reactant 3

HCID 24648Sulfuryl chlorideHCID 516892Sodium BicarbonateHCID 15030566HCID 15030566, compound

Product 1

HCID 15672346HCID 15672346, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

22 g (0.16 mol) of sulfuryl chloride were added dropwise to a solution of 43 g (0.15 mol) of 3-(4-chloro-2-fluoro-5-methylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 250 ml of tetrachloromethane. After the reaction solution had subsequently been stirred for 16 hours, 200 ml of saturated aqueous sodium hydrogen carbonate solution was added dropwise. The organic phase was then separated off, washed using saturated sodium chloride solution, dried over magnesium sulfate, then filtered and finally concentrated. Yield: 46 g.

Workup

  1. customThe organic phase was then separated off
  2. washwashed
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationfinally concentrated

Sources & evidence

ORD record
ord-afb9f3ca69af4b5e983068ce9208a4d4
Source dataset
uspto-grants-2001_01
Patent number
US06175007B1

Reaction notes

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