反应详情

At RT, 2 ml (11.5 mmol, 2.4 eq.) of N-ethyl-N-(propan-2-yl)propan-2-amine were added to a solution of 1.9 g (purity 40%, 4.8 mmol) of ethyl 3-cyclopropyl-2-hydroxypropanoate (racemate) in 100 ml of dichloromethane, followed by the quick addition, at 0° C., of 0.45 ml (5.8 mmol, 1.2 eq.) of methanesulphonyl chloride. The reaction mixture was stirred at RT for 2 h and then quenched with ice. After phase separation, the organic phase was washed with three times with water and once with saturated sodium chloride solution. The combined organic phases were dried (sodium sulphate), filtered and concentrated under reduced pressure. The crude product was used for the next step without further purification.

1. customquenched with ice
2. customAfter phase separation
3. washthe organic phase was washed with three times with water and once with saturated sodium chloride solution
4. dry with materialThe combined organic phases were dried (sodium sulphate)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customThe crude product was used for the next step without further purification