Formic Acid → HCID 21266855, compound

HRID 566627Notes

Reaction equation

HRID 566627 reaction equation
[C:1]1([CH:7]([NH:22][C:23]([C:36]2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:8][NH:9][C:10](=O)[CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=CC=2OC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:42](O)=[O:43]>C(Cl)Cl>[CH3:42][O:43][C:16]1[CH:17]=[CH:18][CH:13]=[CH:12][C:11]=1[CH2:10][N:9]1[CH2:8][CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:22]=[C:23]1[CH3:36]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 21266851HCID 21266851, compound

Product 1

HCID 21266855HCID 21266855, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

The 1-phenyl-1-(tritylamino)-2-[N-(2-methoxybenzyl)acetylamino]ethane, prepared as described in Preparation 1, supra, was detritylated and cyclized by dissolving the intermediate (8.0 g, 14.8 mmol) in 250 ml of methylene chloride and cooling this solution to 0° C. under a nitrogen atmosphere. Formic acid (5.7 ml, 148 mmol) was then added and the reaction mixture was warmed to room temperature and then stirred for 2.5 hours. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. customas described in Preparation 1, supra
  2. temperaturethe reaction mixture was warmed to room temperature

Sources & evidence

ORD record
ord-2a31f3cff43a41a6984f28cc41e809dc
Source dataset
uspto-grants-2001_01
Patent number
US06175013B1

Reaction notes

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