Formic Acid → HCID 21266855, compound

Participants

Reaction Conditions

Reaction Steps

The 1-phenyl-1-(tritylamino)-2-[N-(2-methoxybenzyl)acetylamino]ethane, prepared as described in Preparation 1, supra, was detritylated and cyclized by dissolving the intermediate (8.0 g, 14.8 mmol) in 250 ml of methylene chloride and cooling this solution to 0° C. under a nitrogen atmosphere. Formic acid (5.7 ml, 148 mmol) was then added and the reaction mixture was warmed to room temperature and then stirred for 2.5 hours. The progress of the reaction was monitored by thin layer chromatography.

Provenance & Evidence