Formic Acid → HCID 15480884, compound

HRID 566629Notes

Reaction equation

HRID 566629 reaction equation
[C:1]1([CH2:7][CH:8]([NH:23][C:24]([C:37]2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:9][NH:10][C:11](=O)[CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=CC=2OC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:43](O)=[O:44]>C(Cl)Cl>[CH3:43][O:44][C:17]1[CH:18]=[CH:19][CH:14]=[CH:13][C:12]=1[CH2:11][N:10]1[CH2:9][CH:8]([CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:23]=[C:24]1[CH3:37]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 21266852HCID 21266852, compound

Product 1

HCID 15480884HCID 15480884, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

The intermediate 1-phenyl-2-(tritylamino)-3-[N-(2-methoxybenzyl)acetylamino]propane (8.0 g, 14.4 mmol), prepared as described in Preparation 3, supra, was dissolved in 250 ml of methylene chloride and then cooled to 0° C. under a nitrogen atmosphere. Formic acid (5.5 ml, 144.0 mmol) was then added to the reaction solution and the resulting mixture was then warmed to room temperature. The reaction mixture was then stirred for about 2.5 hours. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. customas described in Preparation 3, supra
  2. temperaturethe resulting mixture was then warmed to room temperature

Sources & evidence

ORD record
ord-db11cf52b01b4700b46eea774c0f4571
Source dataset
uspto-grants-2001_01
Patent number
US06175013B1

Reaction notes

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