Lithium Hydroxide → 2-{4-[5-Chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-cyclopropylpropanoic acid

HRID 56664Notes

Reaction equation

HRID 56664 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]([F:28])([F:27])[F:26])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:20][CH:21]3[CH2:23][CH2:22]3)[C:15]([O:17]CC)=[O:16])[C:10](=[O:24])[CH:9]=2)[CH:7]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]([F:28])([F:26])[F:27])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:20][CH:21]3[CH2:22][CH2:23]3)[C:15]([OH:17])=[O:16])[C:10](=[O:24])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 117622749Ethyl 2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-cyclopropylpropanoate

Product 1

HCID 1176226932-{4-[5-Chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-cyclopropylpropanoic acid

Procedure

35 mg (purity 87%, 0.07 mmol) of ethyl 2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-cyclopropylpropanoate (racemate) were hydrolysed with lithium hydroxide according to General Method 6B. Yield: 60 mg (purity 88%, quant.)

Sources & evidence

ORD record
ord-e8fdf5dd4ebf4c08bdd795ab2f6838c5
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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