HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-chlorophenylboronic acid → tert-Butyl [4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-chlorophenylboronic acid | HCID 44558136 | — |
| Reactant | tert-Butyl (4-bromo-2-oxopyridin-1(2H)-yl)acetate | HCID 117622649 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | tert-Butyl [4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]acetate | HCID 117622756 | — |
Reaction Steps
3.8 g (12 mmol) of tert-butyl (4-bromo-2-oxopyridin-1(2H)-yl)acetate and 3.4 g (14.4 mmol) of 2-bromo-5-chlorophenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) were reacted according to General Method 2A. Yield: 3.9 g (purity 94%, 76% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-af82689336fe49ba992dc6ef4b1c66a6 |
| Source note | uspto-grants-2016_09 |