HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-1-propanol → (R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-1-propanol | HCID 12313 | — |
| Reactant | HCID 20639462 | HCID 20639462 | — |
| Reactant | HCID 86756254 | HCID 86756254 | — |
| Product | (R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline | HCID 978314 | — |
Reaction Steps
(1S,2RS)-6,7-Dimethoxy-2-ethyl-2-(3-hydroxypropyl)-1-(3,4,5-trimethoxyphenyl )-1,2,3,4-tetrahydroisoquinolinium chloride [(1S,2R)/(1S,2S), 2:1] was prepared by alkylation with ethyl iodide/potassium carbonate/dimethylformamide followed by quaternization with 3-chloropropanol (see Synthetic Example 1, procedure a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177445B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-429a7a3c876549aa908bc4ceb686bebe |
| Source note | uspto-grants-2001_01 |