Trifluoroacetic acid → HCID 117622896, compound

HRID 56703Notes

Reaction equation

HRID 56703 reaction equation
[Cl:1][C:2]1[C:3]([C:21]2[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:4][C:5](=[O:20])[N:6]([CH:8]([CH2:16][CH:17]2[CH2:19][CH2:18]2)[C:9]([O:11]C(C)(C)C)=[O:10])[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[C:3]([C:21]2[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:4][C:5](=[O:20])[N:6]([CH:8]([CH2:16][CH:17]2[CH2:18][CH2:19]2)[C:9]([OH:11])=[O:10])[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622753tert-Butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-cyclopropylpropanoate

Product 1

HCID 117622896HCID 117622896, compound

Procedure

245 mg (0.57 mmol) of tert-butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-cyclopropylpropanoate (racemate) were hydrolysed with 20 eq. of TFA according to General Method 6A. Yield: 268 mg (quant.)

Sources & evidence

ORD record
ord-6be5ecf32f0a46fd8f693f05d179f0d8
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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