HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzyloxy-5-cyano-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione → 5-Cyano-2-hydroxy-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzyloxy-5-cyano-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione | HCID 22623911 | — |
| Reactant | HCID 178525683 | HCID 178525683 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 5-Cyano-2-hydroxy-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione | HCID 22624055 | 69% |
Reaction Steps
Following the procedure of Example 52, 2-benzyloxy-5-cyano-6-(pyrrolidin)-1-yl)-benzo[de]isoquinoline-1,3-dione (0.15 g, 0.33 mmol, from Example B2) and a 1.0 M solution of boron tris(trifluoroacetate) in TFA (2 mL) was reacted to give 0.070 g of the title compound, mp 247-248° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177423B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-62ba51488ba04078baf060ef89eb0113 |
| Source note | uspto-grants-2001_01 |