HuagongsheHuagongshe Chemistry Print Report · For research reference only
Einecs 211-027-4 → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Einecs 211-027-4 | HCID 69401 | — |
| Reactant | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine | HCID 117604825 | — |
| Product | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one | HCID 117605586 | — |
Reaction Steps
305 mg (purity 77%, 0.77 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine and 20 eq. of pyridinium chloride were reacted according to General Method 3A. After work-up, the crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 179 mg (80% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b098b5f42e87484490369782a0a6d1f2 |
| Source note | uspto-grants-2016_09 |