HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-[6-(3-Ethoxypropoxy)-2,2-dimethylchroman-4-yl]-N-(2-methoxyethyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-bromo-3-ethoxypropane | HCID 260493 | — |
| Reactant | N-[2,2-dimethyl-6-hydroxychroman-4-yl]-N-(2-methoxyethyl)methanesulfonamide | HCID 17786848 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | N-[6-(3-Ethoxypropoxy)-2,2-dimethylchroman-4-yl]-N-(2-methoxyethyl)methanesulfonamide | HCID 9866555 | — |
Reaction Steps
0.5 g (1.5 mmol) of N-[2,2-dimethyl-6-hydroxychroman-4-yl]-N-(2-methoxyethyl)methanesulfonamide (Example 16b) was reacted with potassium carbonate and 3-ethoxy-1-bromopropane analogously to Example 1g. After column chromatography on silica gel using n-heptane/EA (5:1), 0.35 g of oily product was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177449B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-6c0ee2ab4c9c4e39be2ec6ec07a998b8 |
| Source note | uspto-grants-2001_01 |