HRID56709

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11030558

(5-Chloro-2-methoxypyridin-4-yl)boronic acid

C6H7BClNO3

HCID20269857

2-Bromo-4-chloro-1-(trifluoromethyl)benzene

C7H3BrClF3

PRODUCTS

生成物

结构：COc1cc(-c2cc(Cl)ccc2C(F)(F)F)c(Cl)cn1

HCID117605620

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.NCCc1[c-]cccc1.[Cl][Pd+]

催化剂HCID54751079

Chloropalladium(1+) 2-(2-aminoethyl)benzen-1-ide--dicyclohexyl[2',4',6'-tri(propan-2-yl)[1,1'-biphenyl]-2-yl]phosphane (1/1/1)

C41H59ClNPPd

PROCEDURE

实验过程

443 mg (2.20 mmol) of 5-chloro-2-methoxypyridin-4-ylboronic acid and 571 mg (2.20 mmol) of 2-bromo-4-chloro-1-(trifluoromethyl)benzene in the presence of XPhos precatalyst were reacted according to General Method 2B. Yield: 193 mg (purity 93%, 25% of theory)