HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Chloro-2-methoxypyridin-4-yl)boronic acid → 5-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Chloro-2-methoxypyridin-4-yl)boronic acid | HCID 11030558 | — |
| Reactant | 2-Bromo-4-chloro-1-(trifluoromethyl)benzene | HCID 20269857 | — |
| Catalyst | XPhos Palladacycle | HCID 54751079 | — |
| Product | 5-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine | HCID 117605620 | — |
Reaction Steps
443 mg (2.20 mmol) of 5-chloro-2-methoxypyridin-4-ylboronic acid and 571 mg (2.20 mmol) of 2-bromo-4-chloro-1-(trifluoromethyl)benzene in the presence of XPhos precatalyst were reacted according to General Method 2B. Yield: 193 mg (purity 93%, 25% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-fa6e63b98ed947ad9d7b691e79ba8e50 |
| Source note | uspto-grants-2016_09 |