Pyridinium hydrochloride → 5-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]pyridin-2(1H)-one

HRID 56710Notes

Reaction equation

HRID 56710 reaction equation
[Cl:1][C:2]1[C:3]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[C:17]([F:20])([F:19])[F:18])=[CH:4][C:5]([O:8]C)=[N:6][CH:7]=1.Cl.[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[C:3]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[C:17]([F:18])([F:19])[F:20])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21584435Pyridinium hydrochlorideHCID 1176056205-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine

Product 1

HCID 1176050785-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]pyridin-2(1H)-one

Procedure

193 mg (purity 93%, 0.56 mmol) of 5-chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine and pyridinium hydrochloride were reacted according to General Method 3A. Yield: 123 mg (72% of theory)

Sources & evidence

ORD record
ord-b35b67511b614215be80aa4dd7ee22ee
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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