Trifluoroacetic acid → HCID 21264426, compound

HRID 567109Notes

Reaction equation

HRID 567109 reaction equation
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]([CH:8]=[N:9][CH2:10][CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:8]2[C:16]3[CH:15]=[CH:14][S:13][C:12]=3[CH2:11][CH2:10][NH:9]2)=[CH:17][CH:18]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21264431HCID 21264431, compound

Product 1

HCID 21264426HCID 21264426, compoundYield 85%

Procedure

The above (4-nitrobenzylidene)-(2-thiophen-2-yl-ethyl)-amine (1 g, 3.8 mmol) was added trifluoroacetic acid (100 ml) at once (strongly exothermic reaction). The reaction mixture was stirred at room temperature for 72 hours, then evaporated in vacuo. Crystallisation from a mixture of diethyl ether and dichloromethane afforded 1.2 g (85%) of the title compound.

Workup

  1. customstrongly exothermic reaction)
  2. customevaporated in vacuo
  3. customCrystallisation
  4. additionfrom a mixture of diethyl ether and dichloromethane

Sources & evidence

ORD record
ord-53bed8853353406fb7990c405fdf2226
Source dataset
uspto-grants-2001_01
Patent number
US06177443B1

Reaction notes

Loading…