Water → HCID 21264591, compound

HRID 567116Notes

Reaction equation

HRID 567116 reaction equation
[CH3:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][CH2:5][C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8](Cl)=[O:9].[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.O>COC(C)(C)C>[CH3:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][CH2:5][C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)=[O:9]

Participants

5

Reactant 3

HCID 962WaterHCID 8083MorpholineHCID 156802362-[(2-Methylphenoxy)methyl]benzoyl chloride

Product 1

HCID 21264591HCID 21264591, compoundYield 51.4%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

At 20 to 30° C., 2.6 g (0.01 mol) of 2-(2-methylphenoxymethyl)benzoyl chloride (EP-A 493 711, page 22) are added dropwise to a solution of 1.8 g (0.02 mol) of morpholine in 40 ml of tert-butyl methyl ether. The mixture is admixed with water and the organic phase is separated off, dried over sodium sulphate and concentrated under reduced pressure. The residue is recrystallized from 5 ml of methanol. 1.6 g (51.4% of theory) of N-[2-(2-methylphenoxymethyl)-benzoyl]-morpholine are obtained.

Workup

  1. customthe organic phase is separated off
  2. dry with materialdried over sodium sulphate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue is recrystallized from 5 ml of methanol

Sources & evidence

ORD record
ord-73dc3005735b4d4b9c7e494b52171e7c
Source dataset
uspto-grants-2001_01
Patent number
US06177459B1

Reaction notes

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