反应详情

At 20 to 30° C., 2.6 g (0.01 mol) of 2-(2-methylphenoxymethyl)benzoyl chloride (EP-A 493 711, page 22) are added dropwise to a solution of 1.8 g (0.02 mol) of morpholine in 40 ml of tert-butyl methyl ether. The mixture is admixed with water and the organic phase is separated off, dried over sodium sulphate and concentrated under reduced pressure. The residue is recrystallized from 5 ml of methanol. 1.6 g (51.4% of theory) of N-[2-(2-methylphenoxymethyl)-benzoyl]-morpholine are obtained.

1. customthe organic phase is separated off
2. dry with materialdried over sodium sulphate
3. concentrationconcentrated under reduced pressure
4. customThe residue is recrystallized from 5 ml of methanol