1,3-Propanediamine → Deacetylvinblastine 3-aminopropyl amide

Participants

Reaction Conditions

Reaction Steps

To a cooled (−15° C.) a DMF solution (3 ml, 0.0624 mmol) of deacetylvinblastine acid azide (synthesis described in Example 9, Step C) was added 120 μl of 1,3-diaminopropane in DMF (2 ml). The reaction was stirred at −10° C. for 1 hr, filtered and concentrated to dryness to yield (11).

Provenance & Evidence