huagongshe.com
HRID567143

反应详情

EQUATION

反应方程式

HRID 567143 的结构方程式

REACTANTS

反应物

2
结构：NCCCN
HCID428

1,3-Diaminopropane

C3H10N2

结构：CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@@H]3C45CCN4CC=C[C@](CC)([C@H]45)[C@@H](O)[C@]3(O)C(=O)OC)C2)C1
HCID197026

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@@H]3C45CCN4CC=C[C@](CC)([C@H]45)[C@@H](O)[C@]3(O)C(=O)OC)C2)C1.[NH-]CCCN
HCID131721105

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

CONDITIONS

反应条件

温度
-10 °C

PROCEDURE

实验过程

To a cooled (−15° C.) a DMF solution (3 ml, 0.0624 mmol) of deacetylvinblastine acid azide (synthesis described in Example 9, Step C) was added 120 μl of 1,3-diaminopropane in DMF (2 ml). The reaction was stirred at −10° C. for 1 hr, filtered and concentrated to dryness to yield (11).

WORKUP

后处理

  1. filtrationfiltered
  2. concentrationconcentrated to dryness