反应详情

A mixture of methyl 4-(4-chlorobenzoyl)-4-phenoxycarbonyloxybutyrate (61.2 g), ammonium acetate (62.2 g) and acetic acid (300 ml) was stirred under reflux for 1.5 hours. The reaction mixture was concentrated, water was added to the resulting residue, and the crystals thus precipitated were collected by filtration. These were recrystallized from methanol to give colorless needles of methyl 3-[4-(4-chlorophenyl)-2-oxo-4-oxazolin-5-yl]propionate (36.6 g, 79%). m.p. 147-148° C.

1. temperatureunder reflux for 1.5 hours
2. concentrationThe reaction mixture was concentrated
3. additionwater was added to the resulting residue
4. customthe crystals thus precipitated
5. filtrationwere collected by filtration
6. customThese were recrystallized from methanol