2-Bromopropionic acid → HCID 117622834, compound

HRID 56717Notes

Reaction equation

HRID 56717 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:17]([F:19])[F:18])=[C:6]([C:8]2[C:9]([C:15]#[N:16])=[CH:10][NH:11][C:12](=[O:14])[CH:13]=2)[CH:7]=1.Br[CH:21]([CH3:25])[C:22]([OH:24])=[O:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:17]([F:19])[F:18])=[C:6]([C:8]2[C:9]([C:15]#[N:16])=[CH:10][N:11]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])[C:12](=[O:14])[CH:13]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 117292-Bromopropionic acidHCID 117605519HCID 117605519, compound

Product 1

HCID 117622834HCID 117622834, compound

Procedure

88 mg (0.31 mmol) of 4-[5-chloro-2-(difluoromethyl)phenyl]-6-oxo-1,6-dihydropyridin-3-carbonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 45° C. Yield: 88 mg (purity 92%, 73% of theory)

Workup

  1. customaccording to General Method 4A at 45° C

Sources & evidence

ORD record
ord-577e3cffd4bb4999b6876b17d256dd70
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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