Iodoethane → HCID 18376428, compound

HRID 567180Notes

Reaction equation

HRID 567180 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([S:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[O:11][C:12]=2[CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:4][CH:3]=1.I[CH2:26][CH3:27]>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([S:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[O:11][C:12]=2[CH2:13][CH2:14][C:15]([O:17][CH2:26][CH3:27])=[O:16])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 15480890HCID 15480890, compound

Product 1

HCID 18376428HCID 18376428, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Water was added to a mixture which was obtained by ) reacting 4-(4-chlorophenyl)-2-(2-pyridylthio)-5-oxazolepropionic acid with iodoethane in the same manner as Example 52. This was extracted with ethyl acetate. The ethyl acetate layer was washed with water, and dried (MgSO4). The residue obtained by evaporated the solvent was subjected to silica gel column chromatography. From the fraction eluted with ethyl acetate-hexane (1:4, v/v), obtained was ethyl 4-(4-chlorophenyl)-2-(2-pyridylthio)-5-oxazolepropionate(yield: 96%) as an oily substance.

Workup

  1. customwas obtained by )
  2. extractionThis was extracted with ethyl acetate
  3. washThe ethyl acetate layer was washed with water
  4. dry with materialdried (MgSO4)
  5. customThe residue obtained
  6. customby evaporated the solvent
  7. washFrom the fraction eluted with ethyl acetate-hexane (1:4, v/v)
  8. customobtained

Sources & evidence

ORD record
ord-e6a6ae9b014e44a8a09701e8c46218ba
Source dataset
uspto-grants-2001_01
Patent number
US06177452B1

Reaction notes

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