Pyridinium hydrobromide → 4-Chloro-2-[5-(difluoromethyl)-2-oxo-1,2-dihydropyridin-4-yl]benzonitrile

HRID 56728Notes

Reaction equation

HRID 56728 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([CH:16]([F:18])[F:17])=[CH:14][N:13]=[C:12]([O:19]C)[CH:11]=2)[CH:3]=1.Br.[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([CH:16]([F:17])[F:18])=[CH:14][NH:13][C:12](=[O:19])[CH:11]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 21226041Pyridinium hydrobromideHCID 1176048794-Chloro-2-[5-(difluoromethyl)-2-methoxypyridin-4-yl]benzonitrile

Product 1

HCID 1176049664-Chloro-2-[5-(difluoromethyl)-2-oxo-1,2-dihydropyridin-4-yl]benzonitrile

Procedure

216 mg (0.73 mmol) of 4-chloro-2-[5-(difluoromethyl)-2-methoxypyridin-4-yl]benzonitrile and pyridinium hydrobromide were reacted according to General Method 3A. Yield: 215 mg (purity 64%, 67% of theory)

Sources & evidence

ORD record
ord-b2ca3f1fe6934a5da59883a869dc3121
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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