HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium hydrobromide → 4-Chloro-2-[5-(difluoromethyl)-2-oxo-1,2-dihydropyridin-4-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium hydrobromide | HCID 21226041 | — |
| Reactant | 4-Chloro-2-[5-(difluoromethyl)-2-methoxypyridin-4-yl]benzonitrile | HCID 117604879 | — |
| Product | 4-Chloro-2-[5-(difluoromethyl)-2-oxo-1,2-dihydropyridin-4-yl]benzonitrile | HCID 117604966 | — |
Reaction Steps
216 mg (0.73 mmol) of 4-chloro-2-[5-(difluoromethyl)-2-methoxypyridin-4-yl]benzonitrile and pyridinium hydrobromide were reacted according to General Method 3A. Yield: 215 mg (purity 64%, 67% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b2ca3f1fe6934a5da59883a869dc3121 |
| Source note | uspto-grants-2016_09 |