HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → Isotretinoin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1,4-Pentadien-3-ol, 3-methyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)- | HCID 6436846 | — |
| Reactant | Triphenylphosphinehydrochloride | HCID 12196763 | — |
| Reactant | Hydroxy butenolide | HCID 21773091 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | Isotretinoin | HCID 5282379 | — |
Reaction Steps
43 g of the mixture of retinoic acids from the condensation of hydroxy butenolide, vinyl beta-ionol and triphenylphosphine hydrochloride in 10 ml of ethanol are treated with 15 g of a 50% potassium hydroxide aqueous solution, subsequently diluted to 200 mL with water, added with 30 mg of Bengal rose, then irradiated with a 18 Watt lamp for 12 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177579B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-53c33f094f89499a89ea20c9541d821d |
| Source note | uspto-grants-2001_01 |