HRID567404

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1501912

4'-Bromomethyl-2-cyanobiphenyl

C14H10BrN

结构：COC(=O)c1cccc([N+](=O)[O-])c1NC(=O)OC(C)(C)C

HCID9965968

Methyl 2-[(tert-butoxycarbonyl)amino]-3-nitrobenzoate

C13H16N2O6

HCID86594832

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cccc([N+](=O)[O-])c1N(Cc1ccc(-c2ccccc2C#N)cc1)C(=O)OC(C)(C)C

HCID10874596

AGN-PC-0NC1NR

C27H25N3O6

PROCEDURE

实验过程

A method according to claim 1, wherein said reaction is carried out between (1) a mixture containing 2-(4-bromomethylphenyl)benzonitrile and 2-(4,4-dibromomethylphenyl)benzonitrile and (2) methyl 2-tert-butoxycarbonylamino-3-nitrobenzoate to give methyl 2-[N-t-butoxycarbonyl-N-[(2′-cyano-biphenyl-4-yl)methyl]amino]-3-nitrobenzoate.

WORKUP

后处理

customreaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5cb46d7d21114f58a6ec3b0cdfbf55e5
来源数据集: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06177587B1
来源说明: uspto-grants-2001_01

反应 SMILES

Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=2[C:11]#[N:12])=[CH:5][CH:4]=1.BrCC1(CBr)C=CC(C2C=CC=CC=2C#N)=CC1.[C:35]([O:39][C:40]([NH:42][C:43]1[C:52]([N+:53]([O-:55])=[O:54])=[CH:51][CH:50]=[CH:49][C:44]=1[C:45]([O:47][CH3:48])=[O:46])=[O:41])([CH3:38])([CH3:37])[CH3:36]>>[C:35]([O:39][C:40]([N:42]([C:43]1[C:52]([N+:53]([O-:55])=[O:54])=[CH:51][CH:50]=[CH:49][C:44]=1[C:45]([O:47][CH3:48])=[O:46])[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=2[C:11]#[N:12])=[CH:5][CH:4]=1)=[O:41])([CH3:38])([CH3:36])[CH3:37]