反应详情

温度

80 °C

At 0° C., 758 mg (4.5 mmol) of 2-iodopropane and 948 mg (6.9 mmol, 2 eq.) of potassium carbonate were added to a solution of 861 mg (3.4 mmol) of 4-iodo-6-methoxypyridin-3-ol in 15 ml of acetone and the mixture was stirred at 80° C. overnight and concentrated under reduced pressure. After addition of water/ethyl acetate and phase separation, the aqueous phase was extracted with ethyl acetate. The combined organic phases were dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 741 mg (73% of theory)

1. concentrationconcentrated under reduced pressure
2. additionAfter addition of water/ethyl acetate and phase separation
3. extractionthe aqueous phase was extracted with ethyl acetate
4. dry with materialThe combined organic phases were dried (sodium sulphate)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure