Trifluoroacetic acid → HCID 117622671, compound

HRID 56756Notes

Reaction equation

HRID 56756 reaction equation
C([C:5]([N:13]1[CH:18]=[C:17]([O:19][CH3:20])[C:16]([C:21]2[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:15][C:14]1=[O:30])([CH2:9][CH:10]([CH3:12])[CH3:11])[C:6]([OH:8])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[Cl:27][C:25]1[CH:24]=[CH:23][C:22]([C:28]#[N:29])=[C:21]([C:16]2[C:17]([O:19][CH3:20])=[CH:18][N:13]([CH:5]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:6]([OH:8])=[O:7])[C:14](=[O:30])[CH:15]=2)[CH:26]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118877925tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methylpentanoic acid

Product 1

HCID 117622671HCID 117622671, compound

Procedure

178 mg (purity 92%, 0.38 mmol) of tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methylpentanoic acid (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 165 mg (purity 85%, 98% of theory)

Sources & evidence

ORD record
ord-fbddc31866cc48adade634d3d5352b99
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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