反应详情

50.21 g (100.0 mmol) of perfluorooctanesulfonyl fluoride is added in drops to a mixture of 10.62 g (105.0 mmol) of triethylamine and 10.72 g (100.0 mmol) of benzylamine at 80° C. while being stirred vigorously. It is stirred for 2 days at 80° C., the reaction mixture is mixed with 300 ml of water and extracted 3 times with ethyl acetate. The combined organic extracts are dried on sodium sulfate, filtered and concentrated by evaporation. The residue is chromatographed on silica gel (mobile solvent: dichloromethane/methanol=4/1).

1. stirringIt is stirred for 2 days at 80° C.
2. extractionextracted 3 times with ethyl acetate
3. customThe combined organic extracts are dried on sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated by evaporation
6. customThe residue is chromatographed on silica gel (mobile solvent: dichloromethane/methanol=4/1)